Being that this is the only time I’ve heard of this happening I have to assume that something was changed somewhere. Are you sure you haven’t made any changes to any of your files? Your home.php or front-page.php file? Functions.php file?
The fact that your other pages work fine points to the home file possibly having an error on it.
Are you running the latest version of Genesis?
Have you tried updating to the latest version of the child theme? Or maybe re-uploading the theme?
What all have you tried so far?