@ggsalas, I’ve been developing with the Epik theme on Genesis 2.0 with no problems for the past month.
In one case I updated the theme to support the HTML5 markup of Genesis 2.0, which works just fine! This is how I updated the theme => http://expressitwebdesign.com/how-to-convert-genesis-child-theme-to-html5/
I’m sure you are aware that Genesis 2.0 wont “officially” be launched until after WordPress 3.6…so there may be more changes later, but as of now all things seem to work well for me!